【摘要】 目的 :用缬沙坦 ( valsartan)和苯那普利 ( benazepril)干预自发性高血压大鼠 ( SHR) ,观察大鼠主要组织内肾素—血管紧张素活性变化。　　方法 :将 SHR随机分成 4组 (生理盐水组、苯那普利组、小剂量缬沙坦组、大剂量缬沙坦组 ,各组 n=6) ,并设 WistarKyoto( WKY)大鼠为血压正常对照组 ( WKY大鼠对照组 ,n=6) ,用放射免疫测定法观察各组血浆和主要器官组织内肾素—血管紧张素活性和血管紧张素 ( Ang )水平。　　结果 :1SHR的 4组心、脑、肾、肝中肾素活性较 WKY大鼠对照组均明显增高 ( P<0 .0 5 ) ,组织中 Ang 水平亦较WKY大鼠对照组增高。 2用苯那普利组干预 4周后的 SHR,血浆和肾组织中肾素活性较生理盐水组明显升高 ,而血浆和各组织中 Ang 水平均有轻度下降 ( P>0 .0 5 )。3大剂量缬沙坦组、小剂量缬沙坦组干预 4周后的 SHR血浆和心、肾、肝组织中肾素活性较生理盐水组增高 ( P<0 .0 5或 <0 .0 1) ,且 SHR心、肾、肝组织中肾素活性大剂量缬沙坦组干预 4周后又明显高于苯那普利组 ;大剂量缬沙坦组、小剂量缬沙坦组血浆、各组织 Ang 水平均明显增高 ( P<0 .0 5或 <0 .0 1)。　　结论 :实验表明 SHR血浆和组织内肾素—血管紧张素系统较 WKY大鼠活跃。用血管紧张素转换酶抑制剂和 Ang 的 型受体拮抗剂更多还原

【Abstract】 Objective:Levels of renin angiotensin system(RAS) in main organs of spontaneously hypertensive rats (SHR) with inhibitor of angiotensin converting enzyme (ACE) benazepril and antagonist of I type specific angiotensin Ⅱ receptor valsartan were measured. Methods:SHR were divided into four groups with Wistar Kyoto (WKY) rats group as control ( n =6).We measured the levels of plasma renin activity and angiotensin Ⅱ in main organs of SHR and WKY rats groups by use of radioimmunoassay. Results:①The levels of renin activity of heart,brain,kidney and liver in SHR were significantly higher than those in WKY rats( p <0.05).The levels of angiotensin Ⅱ in heart,brain,kidney,liver and lung in SHR were also higher than those in WKY rats.②After administrating benazepril for 4 weeks,renin activities in plasma and kidney were higher in SHR than those in normol saline group,but the levels of angiotensin Ⅱ in plasma and each organs in SHR were slightly lower ( p >0.05).③After administrating valsartan for 4 weeks,renin activities in plasma,heart,kidney and liver in SHR were higher than those in normol saline group( p <0.05 or<0.01),however renin activities in heart,kidney and liver in SHR after administrating large dosage valsartan for 4 weeks were nigher than those after administrating benazepril group.The levels of angiotensin Ⅱ in plasma,and kidney in SHR after administrating valsartan for 4 weeks were significantly higher( p <0.05 or 0.01). Conclusions:Experiments showed that RAS in plasma and main organs of SHR is more active than that of WKY rat,the RAS activity in tissues varied significantly after administrating ACE inhibitor and angiotensin Ⅱ type 1 receptor antagonist,the former reduced the angiotensin Ⅱ level,the later increased angiotensin Ⅱ level but its level in brain kept relatively stable.更多还原