【摘要】 目的　研究 2型糖尿病 (2型 DM)家系一级亲非 DM同胞的血脂变化。方法　收集江浙籍 2型 DM家系 32 0个。在排除 DM和糖耐量减退 (IGT)的前提下 ,选择先证者同胞为观察组 (347例 ) ,先证者或其同胞的配偶为对照组 (32 6例 ) ,并按年龄和 BMI分成亚组 ,进行血脂水平比较。结果　 2型 DM家系一级亲非 DM同胞 TG、TC、L DL水平升高 ,HDL水平降低 ,年龄超过 40岁以后尤其明显。结论　 2型 DM家系一级亲在糖耐量正常的情况下血脂已开始变化 ,对该糖尿病高危人群尚应进行血脂监测以利早期防治。更多还原

【Abstract】 Objective To study the changes of blood lipid levels in non-diabetic first-degree siblings of type 2 diabetes families.Methods 320 type 2 diabetes families were recruited from Shanghai.The observation group comprised 347 first-degree siblings with normal glucose tolerance (NGT).The control group comprised 326 NGT spouses of probands and siblings.The study groups were divided into subgroups according to age and BMI.Blood lipid levels were compared between the observe and control groups.Results The TC,TG,LDL levels in non-diabetic first-degree siblings of type 2 diabetes families were higher and the HDL level in this population was lower than control,especially in those aged over 40yr.Conclusion Lipid abnormalities may be present in NGT relatives of type 2 diabetes families.Blood lipid monitoring is important for the early prevention and treatment of DM.更多还原