【摘要】 目的 :探讨蛛网膜下腔出血 (SAH)后脑血流量、体感诱发电位 (SEP)潜伏期的改变及其与一氧化氮 (NO)的关系。方法 :对假手术对照组和SAH模型组大鼠检测 2 4h内局部脑血流量 (rCBF)、SEP潜伏期和血清及脑组织NO含量动态变化。结果 :非开颅刺破Willis环的方法可成功地诱发SAH。SAH后rCBF立即降低 ,在 2 4h内无恢复趋势。SEP潜伏期于SAH后 1h开始至 2 4h明显延长。血清和脑组织NO含量于SAH后 1h开始分别显著减少和明显增加 ,并持续 2 4h。结论 :SEP对SAH后脑缺血损伤的判断有重要意义。血清NO减少及脑组织NO增加分别在脑血管痉挛发生及加重脑缺血损伤中起重要作用更多还原

【Abstract】 Aim: To investigate the changes of cerebral blood flow, latency of somatosensory evoked potential (SEP) , and nitrio oxide (NO) levels in both serum and brain tissue after subarachnoid hemorrhage (SAH). Methods:Rat SAH models were used and animals were divided into sham-operated group and SAH model group. Dynamic changes of regional cerebral blood flow(rCBF), latency of SEP, and NO levels in both serum and brain tissues were detemined within 24 hours after operation. Results: The noncraniotomy method used in this study reliably induced SAH in rats. rCBF was decreased immediately after SAH being produced, with no tendency to recover within 24 hours. Latency of SEP was delayed progressively from 1 hour to 24 hours. NO levels in serum and brain tissue were decreased and increased respectively from 1 hour to 24 hours after induction of SAH.Conclusion: SEP is useful in the judgement of brain ischemic damage after SAH. Decrease of NO levels in serum and increase of those in brain tissue are important factors leading to cerebral vasospasm and ischemic brain damage respectively after SAH.更多还原