【摘要】 目的:研究XW630对去卵巢大鼠骨质疏松的影响。方法:血清E₂和骨钙素（BGP）浓度用放射免疫测定法。骨组织计量学用四环素内标法。结果:去卵巢后,血清E₂水平下降61.9％,子宫减轻72.7％,动情次数减少63.6％。XW630治疗13周后,血清BGP浓度增加75.7％,动情次数略增加,但低于假手术组,血清E₂浓度及子宫重量无明显变化。与OVX组相比,XW630组骨组织计量学指标TBV/TTV,TBV/SBV和MTPD增加;Sfract（s）,Sfract（d）,TOS和Svf增加,OMP缩短。结论:XW630增加骨激活频率、骨小梁连接性、稳定性和张力。表明XW630促进骨形成、抑制骨吸收,对生殖系统无影响。更多还原

【Abstract】 AIM: To study the effects of 2-[ 3-estrone-N-ethyl-piperazine-methyl] tetracycline (XW630) on experimental osteoporosis in ovariectomized (OVX) rats. METHODS: Serum estradiol (E2) content and bone 1-car-boxyglutamic acid-containing protein (BGP) content were measured by radioimmunoassay. With undecalcified bone section and tetracycline intraperitoneal labeling, the bone static and dynamic data were studied in right femur samples. RESULTS: After treatment with XW630 2.5 mg·kg-1, serum BGP content increased by 75.7 % but there was no change in serum E2 content and uterus weight compared with OVX rats. Compared with OVX rats, the static data of trabecular bone volume/total tissue volume, trabecular bone volume/sponge bone volume, and mean trabecular plate density were enhanced after treatment with XW630 for 13 wk. The dynamic data of single-labeled surface, double-labeled surface, trabecular osteoid surface, and bone formation rate in tissue level in XW630 group were increased and osteoid maturation period was shortened. CONCLUSION: XW630 enhanced bone activation frequency and increased trabecular connectivity, stability, and strength. XW630 stimulated bone formation and inhibited bone resorption with no ef-fect on reproductive system.更多还原