【摘要】 山东省 1999年共报告麻疹疑似病例 1776例 ,采集血清标本 86 1份 ,采集率为 48 48%。采用酶联免疫吸附试验 (ELISA)捕获法检测麻疹、风疹IgM抗体 ,阳性率分别为 5 9 12 % (5 0 9/ 86 1)和 10 34% (89/ 86 1) ,两者全部阴性者占 30 5 4% (2 6 3/ 86 1)。1337例麻疹暴发疑似病例 ,麻疹、风疹IgM抗体阳性率分别为 5 8 81% (32 7/ 5 5 6 )和 14 5 7% (81/ 5 5 6 ) ;439例散发疑似病例分别为 5 9 6 7% (182 / 30 5 )、2 6 2 % (8/ 30 5 )。首次在 1例典型麻疹确诊病例的咽拭子标本中分离到 1株麻疹野病毒株。ELISA捕获法检测IgM抗体用于麻疹的血清学早期诊断敏感性较高 ,其结果与血清标本采集时间及麻疹疑似病例的最终分类有很大的关系更多还原

【Abstract】 suspected measles cases were reported in Shandong Province in 1999 Among them,861(48 48%) serum specimens were tested for measles and rubella IgM antibodies by Capture IgM ELISA The results showed that 59 12% cases (509/861) were laboratory confirmed as measles and 10 34% (89/861) cases were confirmed as rubella。Of the 1,337(75 28%) outbreak cases, 556(41 58%) serum specimens showed 58 81% (327/556) and 14 5%(81/556) positive to measles and rubella respectively Of the 439(24 72%) sporadic cases,305(69 48%) serum specimens showed 59 67% and 2 62% positive to measles and rubella respectively One measles wild type virus was isolated from a typical measles case The capture IgM ELISA is highly sensitive for early diagnosis of measles and rubella,the results are related to the time of sample collection and the final classification of suspected measles cases更多还原