【摘要】 目的 :探讨高血压的心力衰竭过程中肾上腺髓质素 (ADM )及肾上腺紧张素 (ADT)的变化及作用。方法 :采用特异性放射免疫法 (RIA)测定 2 5例正常人、5 0例原发性高血压患者 (13例高血压、12例高血压左室肥厚、2 5例高血压心力衰竭 )血浆中ADM及ADT的浓度。结果 :(1)随着高血压心脏损害的加重 ,ADM明显增加 ,而ADT变化不大。 (2 )随着高血压心力衰竭中NYHA分级增高 ,ADM/ADT比值变低 ,ADT浓度明显增加 ,ADM代偿速度变慢。结论 :ADM代偿缓慢和ADT分泌过度是高血压心力衰竭过程中血管活性肽调节紊乱的一个特点更多还原

【Abstract】 Aim:To assess the plasma levels of adrenomedullin (ADM) and adrenotensin(ADT) in relation to the development of heart failure in hypertensive patients. Methods:The plasma levels of ADM and ADT were measured by radioimmuniassay(RIA) in 25 normotensive persons and 50 essential hypertensive patients including 13 hypertension,12 hypertension with left ventricular hypertrophy, 25 hypertension with heart failure). Results:(1).With the development of heart failure ,the plasma level of ADM increased significantly,with little chnage of plasma ADT. (2)In hypertensive patients with heart failure,the ratio of ADM/ADT decreased with the deterioration of heart failure Conclusion:The oversecretion of ADT and slow compensation of ADM is a characteristic deregulation of vasoactive peptide in the process of hypertensive heart failure.更多还原