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高血压患者内皮素和一氧化氮与血压节律相关性的研究

Endothelin,Nitric Oxide and Blood Pressure Rhythm in Essential \;Hypertension

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【作者】 涂玲魏炜舒柏华朱欢丽黄骁燕陈莉莉刘晓晴余枢

【Author】 TU Ling, WEI Wei, ZHU Huan li, HUANG Xiao yan,CHEN Li li, LIU Xiao qing, YU Shu (Affiliated Tongji Hospital of Tongji Medical University,Wuhan 430030,China)

【机构】 同济医科大学附属同济医院综合医疗科同济医科大学环境医学研究中心!武汉430030同济?

【摘要】 目的 :探讨高血压患者血浆内皮素 (ET)和血清一氧化氮(NO)与血压节律的相关性。方法 :2 8例高血压患者和 1 7例血压正常人进行动态血压监测和 ET,NO测定。结果 :高血压组 ET增加 ,NO下降。2 8例高血压患者按动态血压监测结果分为勺型和非勺型组 ,在非勺型组 ,ET明显增高(5 3.3± 1 9.1 vs37.8± 1 0 .0 ng/ L) ,NO明显降低 (33.4± 1 2 .7vs 48.4± 1 1 .1 mg/ L ) ;且夜间血压下降与 ET负相关 (r=- 0 .5 2 ,P<0 .0 5 ) ,NO正相关 (r=0 .5 4,P<0 .0 5 )。结论 :高血压病患者内皮素和一氧化氮水平可能参与昼夜血压节律的调节

【Abstract】 Aim:To evaluate relationship between endothelin, nitric oxide and circadian rhythm of blood pressure in essential hypertension. Methods: 28 patients with essential hypertension and 17 patients with normotension were monitored 24 hour blood pressure and examined endothelin, nitric oxide . Results:In hypertension group, ET increased and NO decreased. According to results of the monitoring, 28 patients hypertension were divided dipper hypertension and non dipper hypertension. In non dippers, endothelin was significantly higher (53.3±19.1va37.8±10.0ng/L), nitric oxide was lower(33.4±12.7vs48.411.1mg/L). There were significant negative correlation between nocturnal blood pressure fall and endothelin (r=-0.52, P <0.05) , positive correlation between nocturnal blood pressure fall and nitric oxide (r=0.54, P <0.05) . Conclusion:Endothelin and nitric oxide might have effects in circadian rhythm of blood pressure in essential hypertension.

【关键词】 高血压内皮素一氧化氮勺型非勺型
【Key words】 essential hypertensionendothelinnitric oxidedippernon dipper
  • 【文献出处】 高血压杂志 ,CHINESE JOURNAL OF HYPERTENSION , 编辑部邮箱 ,2000年03期
  • 【分类号】R544.1
  • 【被引频次】23
  • 【下载频次】80
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