【摘要】 探讨高血压病患者外周血单个核细胞的端粒酶活性。方法：用端粒酶ＰＣＲ－ＥＬＩＳＡ方法测定９０例高血压患者和５６例血压正常者外周血端粒酶的活性。结果：高血压组外周血单个核细胞的端粒酶活性比对照组明显增高（分别为５７％和２３％，Ｐ＜０．０００１），而且在Ⅰ级、低危高血压病患者中已有外周血单个核细胞端粒酶活性的增加，这种酶的变化并不随血压的水平和预后危险因素的增加而增加，但规则的降压治疗可使外周血单个核细胞端粒酶活性降低。更多还原

【Abstract】 Aim: To investigate the telomerase activity of peripheral blood mononuclear cells from patients with essentail hypertension. Methods: The telomerase activity of peripheral blood mononuclear cells in 90 hypertensives and 56 normotensives was meassured with Telomerase-PCR-ELIS assay. Results: The telomerase activity of peripheral blood mononuclear cells in hypertensive group was singnificantly increased than that in control group (57 % and 23%, respectively, P< 0. 0001). The increased telomerase were found in first stage and low-risk hypertensives, while it was not correlated with the seventy of hypertension and prognostic risk factors. The telomerase was decreased after antihypertensive treatment.更多还原