【摘要】 小鼠痘病毒急性感染可导致实验小鼠脱脚病 (鼠痘 )发作 ,临床症状明显 ,发病动物短期内大量死亡。近 10年某地区鼠痘发生次数依次为昆明小鼠 (7次 )、NIH小鼠 (3次 )、ICR小鼠 (2次 )和BABL c小鼠 (1次 )。无明显临床症状慢性持续性感染 (隐性感染 ) ,是病毒传播或转化成急性感染主要原因 ,用免疫荧光技术 (IFA)可检测到病毒抗体 ,鸡胚病毒培养意义不大。流行病学调查证实IFA抗体阳性小鼠群体脱脚病发病率显著高于IFA抗体阴性小鼠群体 (P <0 0 0 1)。更多还原

【Abstract】 There were found Mousepox Virus (MPV) acute or chronic infection in laboratory mice.Seven,three,two and one acute infection of MPV occurred in Kunming,NIH,ICR and BALB/c mice respectively in near 10 years.MPV chronic persistent infection was demonstrated by immunofluorescence assay(IFA). Both retrospective and prospective epidemiological surveys confirmed that IFA positive was related to outbreak of Ectromelia. IFA should be applied for monitoring chronic persistent infection of MPV in mice.更多还原