【摘要】 为开发实验小鼠新品系 ,对河南医科大学发现的突变体无毛小鼠进行近交培育。采用强迫杂合性兄妹交配法繁殖 ,现已完成 2 3代近交培育。子代突变性状遗传分析和皮肤移植试验结果显示 :突变体无毛小鼠已达到近交系标准 ,突变位点保持了基因杂合状态 ,建立了携带正常基因和隐性突变基因的无毛小鼠分离近交系。更多还原

【Abstract】 The mutant hairless mice which were discovered in Henan Medical University were close bred to increase new laboratory mouse strains. Using brother-sister inbreeding with forced heterozygosity, the mice had been bred 23 generations. Genetic analysis of mutant character and skin isografting were done in the mice which were close bred more than 20 generations. The results indicated that the mutant mice had reached the norm of inbred strain, And the mutant gene were hybrid. The new segregating inbred strains that carry normal gene and mutant gene were set up.更多还原