【摘要】 目的 :评价手术加放射治疗嗅神经母细胞瘤的疗效。方法 :1975年 1月— 1998年 2月 ,收治嗅神经母细胞瘤 14例 ,按Kadish分期A期 1例 ,B期 8例 ,C期 5例。采用手术加放射治疗 ,原发灶平均剂量 6 0 0 0cGy。结果 :现仍生存 6例 ,已生存时间为 2～ 2 4年。死亡 8例 ,存活时间为 6个月～ 4年。 5例死于局部复发 ,3例死于远处转移。结论 :①嗅神经母细胞瘤病理上易误诊 ,免疫组化和电镜有助于确诊 ;②本病不仅极易局部复发 ,也易发生远处转移 ;③手术加放射是治疗本病的适宜方法。放射治疗对减少术后复发 ,提高手术切除率、控制转移灶均有较大价值更多还原

【Abstract】 Purpose:To evaluate the effects of surgery plus irradiation for olfactory neuroblastoma Methods:From January 1975 to February 1998 fourteen patients with olfactory neuroblastoma (kadish dassification:One case in stage A, 8 in the Stage B, 5 in stage C) were resected and giver radiotherapy to an average dose of 6000 cGy to primary lesions.Results:Six of the 14 patients have been living for 2—24 years. 8 died (5 of recurrence and 3 of distant metastasis)in 6 months to 4 years after diagnosis.Conclusions: There is a high rate of pathologic misdiagnosis in olfactory neuroblastoma. Immunohistologic examination and electron microscopic study are benifitial for diagnosis. Surgery plus irradiation is a suitable method for olfactory neuroblastoma. Radiotherapy is able to reduce local recurrence after surgery and increase resectability rate as well as to control distant metastasis.更多还原