【摘要】 目的　研究链脲佐菌素所致糖尿病性高血糖 (HG)对大鼠缺血性脑损伤的影响。方法　链脲佐菌素引起糖尿病 4周的大鼠造成 10 min前脑缺血 ,观察缺血后脑组织的病理改变和癫痫发作情况。结果　在海马 CA1区和下脚区 ,HG组与正常血糖 (NG)组动物脑神经元损伤程度相似。然而 ,HG组动物有严重的顶叶皮质神经元坏死和“额外脑结构损伤”。 HG组中 42 .1%的动物脑缺血后出现癫痫发作 ,血浆葡萄糖浓度低于 12 mm ol/ L者未见癫痫发作。结论　糖尿病高血糖明显加重缺血后脑损伤并常引起脑缺血后癫痫发作。更多还原

【Abstract】 Objective To explore the effect of streptozotocin induced hyperglycemia (HG) on ischemic brain damage in rats. Methods Streptozotocin induced diabetic rats were subjected to 10 min of forebrain ischemia in 4 weeks after the induction of diabetes. Normoglycemic (NG) rats exposed to the same duration of ischemia,and sham operated diabetic rats (Sham)served as controls.The animals underwent evaluation of histopathological analysis of brain damage and clinical seizures. Results In the CA 1 and in the subcular regions of hippocampus, the severity and distribution of damage were similar between HG and NG animals. However, HG rats had more severe neuronal necrosis in the parietal cortex and the neuronal damage involved“additional brain structures”compared with NG animals. Postischemic seizures developed in 42.1% of HG rats. None of the diabetic rats with plasma glucose concentrations below 12 mmol/L exhibited postischemic seizure activity. Conclusion Diabetic hyperglycemia exacerbates postischemic brain damage and results frequently in postischemic seizures.更多还原