【摘要】 目的　简述侵袭性垂体腺瘤病理学特点 ,其发病机制目前在分子生物学领域的探讨 ,以加深对该病的认识 ,提高诊断率 ,指导临床治疗。方法　参阅近年来相关文献 ,作综述性报道。结果　侵袭性垂体腺瘤在细胞形态上与非侵袭性者差别不显著 ,常规组织病理学检查很难区分。肿瘤中癌基因、抑癌基因以及生长因子、细胞因子等的表达改变 ,与肿瘤的侵袭性显著相关。结论　从癌基因、抑癌基因的改变 ,生长因子、细胞因子、细胞移动相关因子及蛋白降解酶表达水平的变化等方面来检测垂体腺瘤标本 ,不但有助于进一步探索侵袭性垂体腺瘤的发生、发展机制 ,而且可以指导临床诊断、预后评估和及早选择综合性治疗方案。更多还原

【Abstract】 Objective To summarise the pathological behavior and the researches done on invasive pituitary adenoma in the molecular biological field in order to improve its clinical diagnosis and treatment. Methods A comprehensive report was made referring to some pertinent literature. Results The invasiveness of pituitary adenoma could not be reliably predicted by the routine histological appearance of the tumor. Altered expressions of some oncogenes, anti-oncogenes, growth factors and cytokines were significantly correlated with the invasiveness of pituitary adenoma. Conclusion To explore useful markers reflecting the biological activity of invasive pituitary adenoma, such as altered expressions of oncogenes, antioncogenes, growth factors, cytokines and matrix metalloproteinase, is very important to improve its clinical diagnosis, treatment and prognosis evaluation, and help us comprehend the pathogenesis of the tumor at the molecular level.更多还原