【摘要】 目的　研究在碘缺乏和碘过多的情况下 ,大鼠体内红细胞免疫功能与 SOD活性变化。方法　实验利用低碘饲料和碘化钾去离子水复制了不同碘营养状态的大鼠 ,采用 C3b致敏和未致敏的酵母菌及黄嘌呤氧化酶法分别检测红细胞膜上的 C3b受体、免疫复合物及红细胞内 SOD的活性。结果　碘过多时 ,大鼠红细胞 C3b受体花环率、红细胞免疫复合物花环率及红细胞内 SOD活性均较对照组明显增高 ,碘缺乏时与对照组比较差异无显著意义。结论　碘过多时会引起机体红细胞免疫功能的亢进 ,这可能也是构成高碘引起甲状腺肿自身免疫反应发病机制的因素之一。更多还原

【Abstract】 Objective Study the effects of iodine on the red cell immune system and SOD activity in Wistar rats.Methods C3b sensitized yeast cells and C3b unsensitized yeast cells were used to detect C3b receptors and immune complex on red cells,method of xanthine oxidase was applied to detect SOD activity in red cells.Results It was observed that the rosette rate of red cell C3b receptor,the rosette rate of red cell immune complex and SOD activity of red cells in iodine excess Wistar rats were higher than those of normal rats.There was no statistical difference for those between iodine deficiency and normal groups.Conclusions These results suggest that iodine excess can lead to red cell immune hyperfunction.This could be one of pathlogical factors for autoimmune reactions in thyroid induced by iodine excess. [更多还原