【摘要】 目的研究胰岛素样生长因子－Ｉ（ＩＧＦ－Ｉ）对异丙肾上腺素（ＩＳＰ）致大鼠心肌损伤丙二醛（ＭＤＡ），谷 胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的变化影响。方法采用大鼠ＩＳＰ心肌损伤动物模型，以ＩＧＦ－Ｉ作保护因素，分别检 测ＭＤＡ的含量及全血．ＧＳＨ－Ｐｘ的活力。结果ＩＳＰ组大鼠全血ＧＳＨ－ＰＸ活力明显低于ＩＧＦ－Ｉ＋ＩＳＰ组。结论 ＩＧＦ－Ｉ能减少 ＩＳＰ所致心肌损伤时氧自由基的产生，减轻氧自由基对细胞膜的直接损害作用；同时 ＩＧＦ－Ｉ还能提 高内源性抗氧化酶的活性，从而加强内源性自由基的清除能力。更多还原

【Abstract】 Objective Study the effect of MDA、GSH-Px of IGF-I on myocardium injured by ISP. Methods Use rat mycardium injured by ISP as animal models and IGF-I as a protective factor. Measure the level of sedium MDA and active of GSH-Px of blood. Results The level of sedium MDA of rat is obviously higher in group ISP than that in group IGF-I+ISP. The active of blood GSH-Px is apparent lower in group ISP than that in group IGF-I+ISP. Conclusions IGF-I can reduce oxygenic free redicals;attenuate the direct damage of oxygenic free radicals to the membrane of cardial cells and improve the activities of endoantioxidase to clear free radicals.更多还原