【摘要】 目的 探讨谷胱甘肽对抗结核药所致轻、中度肝损害的疗效。方法 抗结核药所致肝损害病人97例,分成2组,治疗组62例,不停抗结核药,加用谷胱甘肽0.6g,静脉滴注,qd×3wk。对照组35例,停用抗结核药,不用谷胱甘肽。2组均采用基础治疗（肌苷、维生素 B₁）。结果 2组总有效率分别为89%和66%,治疗前后血清天冬氨酸转氨酶、丙氨酸转氨酶、总胆红素的差值治疗组分别为:（-69±43）IU·L^-1,（-116±17）IU·L^-1,（-74±14）μmol·L^-1;对照组为（-34±41）IU·L^-1,（-40±14）IU·IL^-1,（-41±11）μmol·L^-1。结论 谷胱甘肽对抗结核药所致的轻、中度肝损害有明显的治疗作用。更多还原

【Abstract】 Objective To study ameliorating effects of glutahione in treating light or moderate liverinjury resulted from antitubercurlosis drugs.Methods Ninety-seven patients with such liver injury were divid-ed into two groups,treatment group and control group.Sixty-two patients of treatment group which still on an-titubercular regimen were given glutathione,0.6g,iv,gtt,qd×3wk.Thirty-five patients of control groupwhich stoppage of the regimen were not given glutathione treatment,2 groups were all given inositol and vita-min B₁.Results Both in group treatment and control,the total effective rates were 89% and 66% respec-tively.In treatment group,the difference of aspartate aminotransferase（AST）,alanine aminotransferase（ALT）,total bilirubin（TB）was（-69±43）IU·L^-1,（-116±17）IU·L^-1,（-74±14）μmol·L^-1;in control group,it was（-34±41）IU·L^-1,（-40±14）IU·L^-1,（-41±11）μmol·L^-1,respectively.Conclusion Glutathione has marked ameliorating antituberculosis effects in treating light or moderate liver in-jury resulted from drugs.更多还原