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pH敏感阳离子聚电解质凝胶的溶胀和释药性能

Swelling and Drug Release Behavior of pH Sensitive Cationic Polyelectrolyte Gels

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【作者】 严俊周春才

【Author】 YAN Jun *, ZHOU Chun Cai (Department of Chemistry,East China Normal University,Shanghai 200062)

【机构】 华东师范大学化学系!上海200062

【Abstract】 A series of pH sensitive cationic polyelectrolyte gel beads were prepared by suspension copolymerization of styrene or methyl methacrylate with diethylaminoethyl methacrylate and divinylbenzene . The study on the swelling behavior of the gels showed that the hydrophobic/hydrophilic composition of the gels had a great influence on the phase transition pH value and the swelling ability of the gels. Both the equilibrium swelling capacity and the swelling rate were pH dependent. The drug release behavior of the gels were well correlated with the swelling behavior of the gels.

  • 【文献出处】 应用化学 ,CHINESE JOURNAL OF APPLIED CHEMISTRY , 编辑部邮箱 ,2000年01期
  • 【分类号】O631
  • 【被引频次】10
  • 【下载频次】162
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