【摘要】 目的 :探明头孢噻肟钠与临床常用注射剂配伍的稳定性。方法 :摸拟临床用药条件 ,选择利巴韦林等 7种常用的注射剂 ,在pH 5 .0 ,10 %葡萄糖注射液中与其配伍 ,考察在 2 5℃ ,3 7℃ 8h内的稳定性。结果 :2 5℃时 ,放置时间对含量变化影响不显著 ,而药物配伍的影响较显著 ,3 7℃时 ,放置时间与配伍变化均对含量有较显著影响。结论 :混合液稳定性受温度、放置时间和pH的影响较显著 (P <0 .0 5 )。更多还原

【Abstract】 Objective:A stability and compatibility of cefotaxime sodium combined with other seven drugs were inspected.Methods:Using conditions of drugs in clinical were imitated, 7 kinds of drugs for injections and cefotaxime sodium were combined, respectively, dissolved with 10% glucose injection solution in the pH 5.0. The stability and compatibility were inspeted 8 h after combination at 25 ℃,37 ℃. Results:The setting time did not produce a significant influence to contend change at 25 ℃, while the drugs compatibleness had more significant influence at 37 ℃. Both of setting time and compatible change had more significant inflence to the contend. Conclusion:The stability of mixture occured significant changes with the changes of temperature, time of store, and pH (P<0.05)。更多还原