【摘要】 为探讨血管紧张素转化酶抑制剂苯那普利对不同时期慢性肾功能衰竭肾小球硬化进程的延缓作用 ,采用实验性慢性肾功能衰竭大鼠模型 ,将 40只大鼠分为正常对照组 (N组 ,10只 )、慢性肾衰疾病组 (D组 ,10只 )、苯那普利早期治疗组 (ET组 ,10只 )及苯那普利晚期治疗组 (L T组 ,10只 ) ,检测各组大鼠的血尿素氮、血肌酐、2 4h尿蛋白排泄率、平均动脉压以及肾小球平均截面积和平均体积。结果显示 ET组大鼠血尿素氮、血肌酐、2 4h尿蛋白排泄率、以及肾小球平均截面积和平均体积均显著低于 D组和 L T组 (P <0 .0 5 ) ;L T组前三项指标水平也较 D组明显下降 (P <0 .0 5 ) ,而平均动脉压、肾小球平均截面积和平均体积虽较 D组有所下降 ,但差异无显著性。提示 :早期给予苯那普利治疗能有效延缓慢性肾衰肾小球硬化的进程 ,而晚期给予苯那普利治疗虽能一定程度地改善肾功能和蛋白尿 ,但对慢性肾衰肾小球硬化的进程并无明显延缓作用更多还原

【Abstract】 To explore the effects of early and late benazepril treatment on the development and progression of glomerulosclerosis in chronic renal failure. Experimental chronic renal failure in rats was induced by uninephrectomy with intravenous adriamycin injection.The following groups of rats were studied:normal control group (N group), chronic renal failure group (D group), early benazepril treatment group (ET group) and late benazepril treatment group (LT group). Plasma nitrogen and creatinine,urinary protein excretion and mean arterial pressure (MAP) as well as the glomerulosclerosis profile of the average areas (A G) and volumes (V G) of glomeruli were measured. Results:Plasma nitrogen and creatinine levels, urinary protein excretion, MAP and the A G and V G of ET group were significantly lower than those of D group and LT group (P<0.05).There was no significant difference in MAP, A G and V G between LT group and D group although plasma nitrogen and creatinine levels, urinary protein excretion of LT group were lower than those of D group (P<0.05).This study shows that early benazepril treatment prevents the development and progression of glomerulosclerosis in chronic renal failure rats, whereas late benazepril treatment has not significantly attenuated the progression of glomerulosclerosis though the renal function has been improved in chronic renal failure.更多还原