【摘要】 目的　“一锅”重排法合成非甾体消炎镇痛药外消旋萘普生。方法　以卤化铜为选择性卤化剂 ,6 甲氧基 2 丙酰基萘经羰基α 卤化、缩酮化、重排和水解等反应合成外消旋体萘普生。结果　“一锅法”合成萘普生总收率74 0 %～ 92 6 % (以 6 甲氧基 2 丙酰基萘计 )。结论　“一锅重排法”合成萘普生 ,操作简便 ,收率较高更多还原

【Abstract】 AIM To synthesize dl naproxen by rearrangement method. METHODS dl Naproxen was synthesized by halogenation, ketalization, rearrangement and hydrolysis, using cupric halide as halogenation agent. RESULTS Total yields were 74 0%～92 6% based on 6 methoxy 2 propionyl naphthalene. CONCLUSION Total yield was higher by one pot rearrangement approach.更多还原