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夏枯草皂苷A的结构鉴定

STRUCTURE IDENTIFICATION OF VULGARSAPONIN A

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【作者】 田晶肖志艳陈雅研赵玉英王祝举

【Author】 Tian Jing, Xiao Zhiyan, Chen Yayan, Zhao Yuying and Wang Zhuju (Division of Natural Medicinal Chemistry, Beijing Medical University, Beijing 100083)

【机构】 北京医科大学天然药物化学研究室!北京100083

【摘要】 目的:研究夏枯草(Prunella vulgaris L.) 果穗中的化学成分。方法:用色谱法分离夏枯草的化学成分,并用化学及波谱法鉴定其结构。结果:从夏枯草中分离得到6 个化合物,根据理化性质和波谱数据鉴定其结构分别为β香树脂醇(1),α波甾醇(2),豆甾醇(3) ,豆甾7烯3β醇(4),咖啡酸(5) 和2α,3α,24三羟基齐墩果12烯28酸28βD吡喃葡糖酯苷(6)。并将其亲脂性部分甲基化后用气质联用方法进行分析,从中分离鉴定了8 个脂肪酸类化合物。结论:化合物6 为新化合物,命名为夏枯草皂苷A,化合物2 ~5 为首次从夏枯草获得。

【Abstract】 AIM: To study the constituents of the spikes of Prunella vulgaris L. METHODS: The constituents were separated by using various chromatographies and the structures were identified on the basis of chemical and spectral analysis. RESULTS: Six compounds were isolated from the spikes of Prunella vulgaris L., their structures were identified as β amyrin (1), α spinasterol (2), stigmasterol (3), stigmast 7 en 3β ol (4), caffeic acid (5) and 2α,3α 24 trihydroxy olean 12 ene 28 oic acid 28 O β D glucopyranosyl ester (6). In addition, eight fatty acids were isolated and identfied by GC MS from the lipid fraction. CONCLUSION: Compound 6 was a new saponin and named as vulgarsaponin A. Compounds 2~4 were obtained for the first time from this plant.

  • 【文献出处】 药学学报 ,ACTA PHARMACEUTICA SINICA , 编辑部邮箱 ,2000年01期
  • 【分类号】R284
  • 【被引频次】102
  • 【下载频次】670
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