【摘要】 目的 :为探讨nm 2 3-H1mRNA及其蛋白低表达之间相关性及与乳腺癌生物学行为的关系。方法 :应用RT/PCR及免疫组化方法对 5 8例乳腺癌中nm2 3-H1mRNA及其蛋白的表达进行检测。结果 :分别为 44 8% ,48 2 %的乳腺癌伴有nm2 3 -H1mRNA或该基因编码蛋白的低表达 ;nm2 3-H1mRNA与其蛋白表达虽有相关性 ,但并不完全吻合。低水平的nm2 3-H1mRNA或其蛋白与乳癌淋巴结转移呈显著相关。结论 :通过nm2 3 -H1水平的检测对乳癌的转移潜能及预后的判断有较重要的意义更多还原

【Abstract】 Objective:To explore the expression of nm23-H 1 mRNA and its protein in breast cancer and its correlation to the biologic behavior.Method:RT-PCR and immunohistochemical method were explore to detect expression of nm23-H 1 mRNA and the protein in 58 breast cancer.Results:Low level expression of nm23-H 1 mRNA and the protein was showed in 44.8% and 48.2% of examinated cases respectively.The low expression of nm23-H 1 mRNA was correlated with,but not always paralle to the protein expression.The low level expression of nm23-H 1 mRNA or the protein was significantly associated with lymphatic metastasis.Conclusion:It is useful to examine nm23-H 1 expression for evaluating metastatic potential and prognosis of the breast cancer.更多还原