【摘要】 目的 :探讨克林霉素磷酸酯对恶性肿瘤放疗后继发肺部厌氧菌感染的治疗疗效及不良反应。材料和方法 :78例肺部接受过放射治疗的恶性肿瘤患者肺部继发厌氧菌感染随机分为克林霉素磷酸酯治疗组 (实验组 ) 4 1例和甲硝唑治疗组 (对照组 ) 37例。克林霉素磷酸酯 ,每次 30 0～ 6 0 0mg ,每日 2～ 3次 ,疗程 10～ 14d。甲硝唑 ,每次 5 0 0～ 75 0mg ,每日 2次或每 8h 1次 ,疗程 10～ 14d。结果 :(1)实验组痊愈率为 6 8 3% ,对照组为 45 9% ,P <0 .0 5 ,有效率分别为 80 5 % ,5 9 5 % ,P <0 .0 5 ;(2 )实验组致病菌清除率为 75 6 % ,对照组为 5 4 1% ,P <0 .0 5 ,;(3)不良反应发生率实验组为 2 2 % ,对照组为 45 9% ,P <0 .0 5。结论 :克林霉素磷酸酯对肺部放疗后继发肺部厌氧菌感染的治疗疗效好、副作用低更多还原

【Abstract】 Objective:To investigate the therapeutic outcome and effect of Clindamycin Phosphate in the treatment of successive lung infection with anaerobic bacteria after radiotherapy.Materials and Methods:78 patients with malignancy contracting successive lung infection with anaerobic bacteria followed by radiotherapy were randomly divided into 2 groups,41 people (Clindamycin Phosphate treatment group) and 37 people (Miediling control group) Clindamycin phosphate,300～600 mg,Bid or Tid,10～14 days,Miediling 500～750 mg.Bid or once/8h,10～14 days.Result:(1)Both recovery and efficacious rate demonstratd a significant difference respectively between treatment group and control group(68.3% vs 45.9%) (P<0.05),(80.5% vs 59.5%)(P<0.05);(2)There existed a significant difference in the lethal rate to the bacteria between treatment group and control group(75.6% vs 54.1%)(P<0.05);(3)Side effect incidence rate were 22% and 45.9% selarately (P<0.05).Conclusion:The application of clindamycin phosphate in the treatment of successive lung infection with anaerobic bacteria after radiotherapy displayed a better effect and smaller side effect.更多还原