【摘要】 目的观察雷公藤内酯醇的局部刺激作用。方法采用雷公藤内酯醇对家兔、大鼠和小鼠进行局部刺激。结果雷公藤内酯醇1.11 ,2.22 ,4.44mmol·L-1 对兔完整皮肤和破损皮肤均引起明显的红斑及水肿反应 ,病理组织学检查 ,表皮真皮呈明显炎症反应。2.22 ,4.44mmol·L -1 可引起小鼠耳廓明显肿胀。0.55 ,1 11mmol·L-1局部皮下注射可引起大鼠足跖肿胀 ,炎症反应于注射后d3达到高峰 ,并持续7d以上。局部注射可引起明显的疼痛反应以及毛细血管通透性增强。结论雷公藤内酯醇具有局部刺激作用 ,诱导的炎症反应不能为其自身的抗炎作用所拮抗。更多还原

【Abstract】 Aim The effect triptolide(Tri) on local stimulation was observed .Methods Tri solution in different concentrations was applied in rabbits, rats and mice and the respenses were observed .Results 1.11 ,2.22 and 4.44 mmol·L-1 of Tri induced obvious erythema and edema on both intact skin and injured skin of rabbits.The pathological histology revealed the evident inflammation in scarfskin and corium 2.22 mmol·L-1 and 4.44 mmol·L-1 of triptolide significantly induced swelling of auricle in mice.0.55 mmol·L-1 and 1.11 mmol·L-1 of Tri significantly induced swelling of planta in rats.The response of inflammation reached to peak at the third day after hypodermic injection and lasted a week.Tri also significantly induced pain reaction and enhanced the permeability of capillary after local injection in mice.Conclusion Tri has a local stimulation effect and induces inflammation which can not be antagonized by its anti-inflammation effect.更多还原