【摘要】 越来越多的证据表明,肿瘤的发生是多因素作用的结果,与癌基因的激活与抑癌基因的失活有关。研究表明几乎一半人类肿瘤都存在抑癌基因的失活,可见抑癌基因失活与肿瘤生长有着密切的关系。因此,将正常的抑癌基因导入肿瘤细胞,去补偿和代替突变或缺失的抑癌基因治疗策略,将成为肿瘤基因治疗中一种重要的治疗模式。就抑癌基因p53,DCC,nm23,TIMP,p21,p16,bcl X等在恶性肿瘤基因治疗方面的研究进展作一综述。更多还原

【Abstract】 More and more evidence indicated that the formation of tumor is due to multi factors with oncogene activation and anti oncogene inactivation.Studies have sh own that the anti oncogene inactivation was closely related to tumor develo pment because of the findings of anti oncogene inactivation in nearly one half of human tumors.So tumor suppressor gene therapy with normal tumor suppressor gene transfection in to the tumor cells to compensate or replace the mutation or deletion gene will b ecome an important method for malignant tumor therapy.This paper reviews advance s of tumor suppressor gene p53,DCC,nm23,TIMP,p21,p16,bcl X etc al in tumor su ppressor gene therapy for malignant tumors.更多还原