【摘要】 目的　评价碱性成纤维细胞生长因子 (bFGF)滴眼液治疗持续性角膜上皮缺损 (PCED)的临床疗效。方法　观察持续性角膜上皮缺损 (PCED)病人 86例 (包括化学烧伤 18例 ,外伤、手术 2 7例 ,角膜炎 13例 ,其它原因 2 8例 ) ,随机分成bFGF治疗组 ( 4 3例 ) ,素高捷疗组 ( 4 3例 )。bFGF及素高捷疗皆滴眼 4次 /日 ,疗程 14天 ,隔日观察上皮缺损修复和患眼局部症状、体征等指标。结果　 1.bFGF治疗组与素高捷疗对照组各疗效判断指标较治疗前皆有显著性差异 (P <0 0 1) ;2 .bFGF治疗PCED的有效率高于素高捷疗 (P <0 0 5 ) ;3 .bFGF治疗化学烧伤、外伤、手术和角膜炎所引起的PCED的有效率分别为 88 9%、10 0 %和 5 7 1% ;4.观察过程中未见局部刺激和全身不良反应。结论　bFGF滴眼液治疗化学烧伤和外伤、手术后PCED疗效确切 ,安全性高。更多还原

【Abstract】 ObjectiveTo evaluate clinical effect of basic fibroblast growth factor(bFGF) eye drops for persistent corneal epithelial defect(PCED).Methods86 cases with PCED(ie:18 eyes with chemical injury),27 eyes with traumatic and operative injury,13 eyes with keratitis and 28 eyes with other causes) were randomly divided into two groups:43 eyes were treated by bFGF;43 eyes by solcoseryl eye gel only as control.Two groups were treated with bFGF and solcoseryl separately q.i.d.Treatment course was 14 d.Epithelial defect restoration,local symptom and sign,etc.were observed on the other day.Results(1)The difference was significant(P<0 01) in two groups;(2)The effect of bFGF was prior to that of solcoseryl in PCED(P<0 05);(3)The effective rate of bFGF in the chemical burn,traumatic,operative injury and keratitis was 88 9%,100% and 57 1%,respectively;(4)Ocular local stimulates and general side effect were not observed within treatment course.ConclusionbFGF eye drop is valuable and safe for PCED due to chemical,traumatic and operative injuries.更多还原