【摘要】 许多研究表明非酶糖化和葡萄糖自身氧化伴随着游离基的产生,是一个糖化氧化过程。多原醇途径使视网膜内还原型烟酰胺腺嘌呤二核苷酸(NADH)和氧化型烟酰胺腺嘌呤二核苷酸(NAD+)比率升高,模拟低氧反应,改变了视网膜内氧化还原平衡。非酶糖化和山梨醇途径引起的氧化还原损伤是糖尿病视网膜病变(DR)发生的主要原因之一。更多还原

【Abstract】 Many studies show that nonenzymatic glycation and glucose autoxidation which are accompanied by generation of free radicals is a process of glycation and oxidation.The polyol pathway increases the retinal ratio of the reduced form of nicotinamide adenine dinucleotide(NADH) and the oxidized form of nicotinamide adenine dinucleotide(NAD +) causing retinal hypoxia like redox imbalance,or “pseudohypoxia”.Oxidative injury caused by nonenzymatic glycation and the polyol pathway is one of major reasons for the occurrence of diabetic retinopathy(DR).更多还原