【摘要】 对 10 4例持续性频发室性早搏患者 ,采用随机单盲法分别给口服慢心律 15 0mg ,每 6小时一次 (4次/日 )及乙胺碘呋酮 (胺碘酮 ) 2 0 0mg ,每 8小时一次 (3次 /日 ) ,以观察对老年人室性早搏的疗效 ,结果两药有效率分别为 88.46 %、82 .6 9% ,两组药物疗效无明显差异 (P >0 .0 5 ) ,但两药起效时间及副作用却明显差异 ,显效病例中慢心律和胺碘酮 3天、7天内有效率分别为 76 .6 7%、96 .6 7%和 2 8.5 7%、6 4.2 9% ,(P <0 .0 1,P <0 .0 5 ) ,两药累计不良反应分别为 2 8.85 %和 6 7.31% ,且前者较轻 ,不需特殊处理或停药 ,后者多严重 ,需停药或处理。更多还原

【Abstract】 To investigate the efficacy of mexiletine and amiodarone on the aged patients with VPCs,We let 104 patients with sustained and frequent VPCs take ovrly mixiletine 150mg once every six hours for four days and amiodarome 200mg once every eight hours for three days separately in a single-blind random way.The results are the effective rates of the two drugs are 88.40% and 82.69%.Their efficacy of treatmant has no obvious differences(P>0.05).But the time of beginning to have effect and side effects are obviously different.Among the cases having obvious effects,the effective rates of mexiletine and amiodarone in three and seven days are 76.67%,96.67% and 28.57%,64.29%(P<0.01,P<0.05),and the rates of adverse reactions are 28.8% and 67.31%,and also the former is lower needing no special treatment or stop of taking drugs.The latter is mostly serious needing stop of taking drugs or treatment.更多还原