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多乙酰氧基烷基酮和多羟基烷基酮的合成
Synthesis of Polyacetoxyalkyltropones and Polyhydroxyalkyltropones
【摘要】 各种溴代的烷基酚酮的乙酸酯用乙酸酐/三氟乙酸酐/乙酸(以下简称ATA)醋解可得高收率的相应的多乙酰氧基烷基酮,后者经稀酸水解几乎定量地得多羟基烷基酮。部分多乙酰氧基酮对肺癌A549和上皮细胞癌显出抑制活性。
【Abstract】 In this paper, a series of polyacetoxyalkyltropones and polyhydroxyalkyltroponeswere synthesized by the reaction of polybromo- substituted alkyltropolones with acetyl trifuluoroacetate. The results of preliminary pharmacological test indicated that some poly - acetoxyalkyltropones had the inhibition effect against cells of KB and A549 in vitro.
【关键词】 多乙酰氧基烷基酮;
多羟基烷基酮;
醋解;
ATA;
【Key words】 polyacetoxyalkyltropone; polyhydroxyalkyltropone; acetolysis; ATA;
【Key words】 polyacetoxyalkyltropone; polyhydroxyalkyltropone; acetolysis; ATA;
【基金】 国家自然科学基金
- 【文献出处】 有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,2000年04期
- 【分类号】O623.52
- 【被引频次】2
- 【下载频次】53