【摘要】 目的　探讨脑脊液tau蛋白浓度对老年期痴呆 (SD) ,主要包括Alzheimer s病 (AD)和血管性痴呆 (VD)的诊断价值。方法　用双抗体夹心酶联免疫吸附法 (ELISA)检测AD 1 4例、VD 1 2例和年龄匹配的对照组 (NC) 30例脑脊液tau蛋白浓度 ;用简易痴呆量表 (MMSE)、Hachiski缺血指数量表 (HIS)、日常生活能力表 (ADL)、汉米尔顿抑郁量表 (HAMD)和Glasgow昏迷量表 (GCS)检查判断患者或对照者的智能状态并分组。结果　各组tau蛋白浓度分别为 :SD(AD +VD) 4 73± 379pg/ml、AD 484± 386 pg/ml、VD 46 1± 388pg/ml、NC 1 5 1± 6 1 pg/ml,AD、VD、SD与NC组间差异均有极显著性 (P <0 0 0 1 ) ;AD与VD组间差异不显著 (P >0 0 5 ) ;AD组tau蛋白浓度与患者智能损害(MMSE、ADL和CT)具有显著相关性 (P <0 0 5 ) ,VD或SD无此相关性。结论　作为一项生物学指标 ,测定SD病人脑脊液tau蛋白的浓度有助于早期诊断AD和VD。更多还原

【Abstract】 Objective To study the tau value of cerebrospinal fluid(CSF) and its significance in diagnosis of dementia including Alzheimer′s disease(AD) and cerebrovascular dementia (VD).Methods Using a sensitive sandwich enzyme linked immunosorbent assay(ELISA),CSF samples of 14 AD patients,12 VD patients and 30 age matched normal controls(NC) were obtained.Using MMSE,HIS,ADL,Hamilton depression scale(HAMD) and Glasgow coma scale (GCS),the cognitive conditions of all subjects and their diagnoses were judged.Results The mean value of CSF tau of each group were SD(AD+VD)(473 0±379 5pg/ml),AD (483 3±386 0pg/ml) and ND(151 3+60 4pg/ml).The difference among AD,VD,SD and NC groups were very significant ( P< 0 001).The tau concentrations in AD group correlated significantly with the severity of cognitive impairments (MMSE,ALD and CT)( P< 0 05),but not in VD or SD group.Conclusion As a biological marker,the measurement of CSF tau levels in senile dementia(SD) patients is a useful tool in diagnosis of AD in the early stage.更多还原