【摘要】 目的：建立心血管变异性的数学模型，探讨变异性频谱的主要频率成分机理。方法：建立了包含血流动力学和自主神经系统，尤其考虑了心血管中枢整合的闭环控制数学模型。结果：成功地模拟了心血管变异性频谱中的三个主要频率峰。高频峰的频率是呼吸频率与心率之比，低频和极低频可能与交感和副交感神经调节心率的非可加性有关。更多还原

【Abstract】 Purpose: To establish a simple mathematical model for investigating the mechanism of frequency components in cardiovascular variability. Methods: A close-loop model involved in hemodynamic and autonomic systems was developed. Three peaks of very low frequency(VLF), low frequency(LF) and high frequency(HF) were simulated successfully. The frequency of HF is determined by the ratio of respiratory frequency and heart rate. The results also indicated that nonadditivity of heart rate modulation by sympathetic and parasympathetic efferents may play an important role in mechanism of LF and VLF generation.更多还原