【摘要】 目的　研究局部植入顺铂缓释剂 (DDPSRP)在大鼠和狗体内的药代动力学。方法　用原子吸收分光光度法 (灯电流 12 5mA ,波长 2 6 5 9nm)测定血浆顺铂 (DDP)的浓度。结果　大鼠皮下植入DDPSRP后 ,DDP可持续缓慢释放 ;狗静脉注射DDP 4mg·kg-1,其时间 -浓度曲线呈二室模型 ;狗肌肉植入 2mg·kg-1DDPSRP后 ,其有效血浆浓度 -时间曲线呈一室模型特点 ,但其维持有效血浆浓度时间 (0 1mg·L-1)长达 16 8～ 2 6 4h。结论　DDPSRP有显著的缓释作用更多还原

【Abstract】 Objective To study the pharmacokinetics of cisplatin sustained release pellet (DDPSRP) in rats and dogs Methods The concentration of cisplatin (DDP) in plasma was measured by atomic absorption spectrophotometer Results DDP could release slowly and last after subcutaneous embedding of DDPSRP in rats; After intramuscular embedding (ime) of DDPSRP in dogs, the plasma drug concentration time curve showed the characteristics of one compartment model, but the time of effective plasma concentration (0 1 mg·L -1 ) was 164～264 h Conclusion DDPSRP possesses significant sustained release effect更多还原