【摘要】 目的　观察肾综合征出血热乳鼠脑纯化Ⅰ型灭活疫苗在浙江省肾综合征出血热高发疫区大面积人群接种后的安全性 ,考核血清学和中期流行病学效果。方法　采用IFAT法测特异性IgG抗体 ,用MCPENT法测中和抗体滴度。结果　共接种 10 46 0人 ,全程接种者占 97 30 % ,对照 16 15 9人。全程接种后 2周进行血清学观察 ,荧光抗体阳转率为 10 0 0 0 % (6 7/6 7) ,中和抗体阳转率为 44 44 % ,几何平均滴度分别为 72 12和4 6 2。基础免疫 1年后进行加强免疫 ,加强针免前、免后 2周 ,荧光抗体阳性率分别为 2 8 5 7%、 83 33 % ;中和抗体阳性率分别为 14 80 %、 5 5 5 6 %。基础免疫后 2年、 2 5年和 3年 ,荧光抗体阳性率分别为 75 0 0 %、5 3 13 %和 2 2 5 8% ;中和抗体阳性率分别为 35 0 0 %、 31 2 5 %。疫苗近期 (基础免疫后 1年 )和中期 (基础免疫后 2年和 3年 )流行病学防病效果良好。结论　HFRS疫苗近期和中期流行病学防病效果明显 ,取得了良好的经济和社会效益更多还原

【Abstract】 Objective:To Observe the safety,serological efficacy and the longterm epidemiological efficacy character of Type I inactivated HFRS vaccine in population in the focus of HFRS with high incidence of HFRS in Zhejiang province.Methods Immunofluorecent antibody assay was used in testing specific IgG antibody and Mcro-CPE method was used in testing the titer of neutralizing antibody.Results 10460 people were vaccinated,97 30% of them completed their vaccination of full doses.16159 nonvaccinated people living in the same areas where the vaccinees were used as the control group.Two weeks after the injection of the third dose,the seroconversion rate by Immunofluorecent antibody test(IgG) and neutralization test were 100 00%(67/67)and 44 44%,the GMTs of them were 72 12 and 4 62 respectively.Before reinforce,two weeks,1 year,2 5 years and 3 years after reinforce,the rates of seroconversion of immunofiuo rescent antibody bo IFA method were 28 57%,83 33%,75 00%,53 13% and 22 58%.The retes of seroconversion of neutralizing antibody by the Mcro-CPE method were 14 80%,55 56%,35 00%,31 25%.The vaccine was effective and The protection rate in population was 100 00% By the shortterm (1 year after primary immunization) and the middleterm (2 and 3 years after primary immunization) observation.Conclusion HFRS vaccine was epidemiologically effective in the shortterm and the middleterm.更多还原