【摘要】 给 6名健康青年男性受试者皮下注射重组人红细胞生成素 (rhEPO) ,剂量为 3 0IU/kg体重 ,每周 3次 ,注射持续 4周。同时给 4名对照受试者注射安慰剂。采用酶联免疫吸附法 (ELISA)进行指标测定。结果表明 :注射rhEPO能提高血清EPO浓度和转铁蛋白可溶性受体 (TfR)浓度 ;在停药后 1个星期左右的时间内 ,TfR浓度仍保持在较高的水平 ;而血浆总纤维蛋白和纤维蛋白原降解产物 (TDP)含量未发现规律性的变化。结果提示 :血清EPO和TfR浓度有可能作为rhEPO滥用检测的指标。更多还原

【Abstract】 Sixhealthyyoungmalevolunteersweresubcutaneouslyadministeredbyrecombinanthumanerythropoietin (rhEPO)witha dosageof3 0IU/kgbodyweight,threetimesaweekforfourweeks Fourvolunteersascontrolswereadministeredbyequalplacebo Somebiochemicalparameterswereobservedbyenzyme -linkedimmunosorbentassay (ELISA)inthisstudy EPOandtransferrinsol ublereceptor (TfR)concentrationsinserumwereelevatedbytheadministrationofrhEPO TfRconcentrationmaintainedhigherlevel aftertheadministrationofrhEPOwithinoneweek Totaloffibrinogendegradationproductsandfibrindegradationproducts (TDP) concentrationsinplasmachangedirregularly TheresultssuggestedthatserumEPOandTfRconcentrationmightbethevalidatepa rametersonthedetectionofrhEPOmisuse更多还原