【摘要】 目的　在豚鼠肠系膜下神经节 (IMG)细胞上观察不同 5 羟色胺 (5 HT)受体亚型拮抗剂对非胆碱能迟慢兴奋性突触后电位 (LS EPSP)的作用。方法　应用离体细胞内记录技术。结果　赛庚啶 (cyproheptadine ,5 HT1/ 2 受体拮抗剂 )及BRL 2 492 4(5 HT1P受体拮抗剂 )可逆的阻抑 5 HT敏感细胞的LS EPSP ,而mianserin(5 HT2 受体拮抗剂 ) ,MDL72 2 2 2 (5 HT3 受体拮抗剂 ) ,spiperone(5 HT1A受体拮抗剂 )对LS EPSP无显著影响 ;用MCPP(5 HT1P受体激动剂 )持续灌流IMG使 5 HT敏感细胞脱敏后可逆的阻抑LS EPSP的发生。结论　 5 HT敏感细胞的LS EPSP是由 5 HT1P受体介导的。更多还原

【Abstract】 AIM To investigate the effects of several 5-hydroxytryptamine(5-HT) subtype receptor antagonists on late slow excitatory postsynaptic potential(LS-EPSP) of the neurons of guinea pig inferior mesenteric ganglion(IMG). METHODS Intracellular recordings were made from neurons of the isolated guinea pig IMG. RESULTS Cyproheptadine and BRL 24924 suppressed LS-EPSP of 5-HT sensitive neurons reversibly, while mianserin, MDL 72222 and spiperone showed no significant effect. Continuous superfusion of IMG with MCPP suppressed LS-EPSP of 5-HT sensitive neurons by 5-HT 1P receptor desensitizated. CONCLUSION LS-EPSP of 5-HT sensitive neuron is mediated by 5-HT 1P subtype receptor.更多还原