【摘要】 目的　研究八厘麻毒素 (Rh)对离体兔心脏电生理参数的影响。方法　使用Langendorff离体兔心脏灌流模型 ,观察并记录用含Rh浓度为 0 34μmol·L-1和 0 6 8μmol·L-1的K H灌注液灌注兔心脏时 ,其对心脏电生理参数的影响。结果　用含Rh浓度为 0 34μmol·L-1的K H灌注液行Langendorff灌注 ,ARRP和AERP明显延长 (P <0 0 5 ,P <0 0 1) ;转用含Rh浓度为 0 6 8μmol·L-1的K H灌注液行Langendorff灌注 ,ADT ,VDT均明显升高 (P <0 0 5 ,P <0 0 1) ,且ARRP ,AERP ,VRRP和VERP均明显延长 (P <0 0 5 ,P <0 0 1)。结论　Rh能直接作用于心肌 ,升高心房和心室舒张期阈值并延长心房、心室不应期更多还原

【Abstract】 AIM To study effects of rhomotoxin(Rh)on electrophysiologic parameters in isolated perfused rabbit heartMETHODS Perfusing isolated rabbit heart by KrebsHenseleit(KH) perfusion liquid with Rh 034 μmol·L -1 or 068 μmol·L -1 ,its electrophysiologic parameters were observed.RESULTS Perfusing isolated heart with Rh 034 μmol·L -1 prolonged ARRP and AERP(P<005,P<001);Perfusing isolated heart with Rh 068 μmol·L -1 increased ADT and VDT (P<005,P<001),prolonged ARRP,AERP,VRRP and VERP(P<005,P<001)CONCLUSION Rh might have a effect of increasing atrial and ventricular diastolic threshold, prolongating atrial and ventricular refractory period by direct action on rabbits myocardial muscle更多还原