【摘要】 目的　探讨肝脏在肾病综合征低白蛋白血症和高脂血症发生机制中的作用。方法　观察肝脏、肾脏被阿霉素同时或分别作用后 ,大鼠血浆白蛋白和血脂水平变化。结果　双肾用阿霉素大量蛋白尿 (B)组、肝脏用阿霉素 (C)组血浆白蛋白较正常 (D)组降低 ,但其降低的程度远低于经典肾病 (A)组 (P <0 .0 1)。B组血总胆固醇和甘油三酯较D组升高 (P<0 .0 1)。C组甘油三酯和载脂蛋白 -A较D组升高 (P<0 .0 1)。结论　致病因子对肝脏的直接作用导致肝脏生理功能的改变 ,可能与阿霉素肾病低白蛋白高脂血症的发生有关更多还原

【Abstract】 Objective To further explore the role of the liver in the pathogenesis of nephrotic hypoalbuminemia and hyperlipidemia in rats. ?Methods Serum albumin ,cholesterol, triglyceride and apolipoprotein in rats were determined after exposing the kindeys and/or the liver to adriamycin simultaneously and separately.?Results The Serum albumin levels were decreased in group B and C where the kidneys and the liver were exposed to adriamycin separately,but they were significantly higher than that in group A when the rats were perfused with adriamycin by tail vein( P <0.01). Serum cholesterol and triglyceride in group B were increased and serum triglyceride and apolipoprotein A in group C were increased( P <0.01).?Conclusion The results suggest that the alteration of liver functions modulation of haptocytes induced by a pathogen may be related to the genesis of nephrotic hypoalbuminemia and hyperlipidemia ,at least in the adriamycin induced nephrotic rats.更多还原