【摘要】 目的：探讨谷胱甘肽对抗结核药所致轻、中度肝损害的疗效。方法：抗结核药所致肝损害病人９７例，分成２组，治疗组６２例，不停抗结核药，加用谷胱甘肽 ０． ６ｇ，静脉滴注，ｑｄ × ３ｗｋ。对照组 ３５例，停用抗结核药，不用谷胱甘肽。２组均采用基础治疗(肌苷、维生素Ｂ₁)。结果：２组总有效率分别为８９％和 ６６％，治疗前后血清天冬氨酸转氨酶、丙氨酸转氨酶、总胆红素的差值治疗组分别为：（－ ６９±４３）ＩＵ·Ｌ^-1，（－１１６±１７） ＩＵ·Ｌ^-1，（-７４±１４）μｍｏｌ· Ｌ^-1；对照组为：（－３４± ４１） ＩＵ· Ｌ^-1，（－ ４０±１４） ＩＵ· Ｌ^-1，（－ ４１±１１）μｍｏｌ·Ｌ^-1。结论：谷胱甘肽对抗结核药所致的轻、中度肝损害有明显的治疗作用。更多还原

【Abstract】 AIM: To study ameliorating effects of glutathione in treating light or moderate liver injury resulted from antituberculosis drugs. METHODS: Ninety-seven patients with such liver injury were divided into two groups, treatment group and control group. Sixty-two patients of treatment group [M 28, F 34, age （34 ± s 12） a] wich still on antitubercular regimen were given glutathione, 0. 6 g, iv, gtt, qd× 3 wｋ. Thirty-five Patients of control group which stoppage of the regimen were not given glutathione treatment, 2 groups were all given inositol 0. 4 g, ｉv, gtt, qｔｔ and vitamin B₁ 10 mg, po, tid. RESULTS: Both in group treatment and control, the total effective rates were 89% and 66% respectively. In treatment group, the difference of aspartate aminotransferase （AST ）, alanine aminotransferase （ALT）, total bilirubin （TB） was （- 69 ±43） IU.L^－１, （－ 116± 17） IU·L^－1, （－ 74 ± 14） μmol.L^-1; in control group, it was （- 34± 41） IU· L^-l, （-40±14） IU·L^-1, （-41±１１） μmol·L^－l, respectively. CONCLUSION: Glutathione has marked ameliorating antituberculosis effects in treating light or mederate liver injury resulted from drugs.更多还原