【摘要】 目的：探讨糖尿病患者骨质疏松的发生率及敏感检测指标。方法：对４６例糖尿病患者和对照组４６名正常人，用放射免疫法测定血清骨钙素，用单光子吸收法测定骨密度，并对骨钙素与骨密度进行相关分析。同时检测血钙、磷、碱性磷酸酶等。结果：糖尿病患者的骨钙素［（３．３±１．４）μｇ／Ｌ］与骨密度［（０．６７±０．１１）ｇ／ｃｍ２］均明显低于对照组［分别为（４．６±１．２）μｇ／Ｌ、（０．７８±０．１２）ｇ／ｃｍ２］，（Ｐ＜０．００１）。骨钙素水平与骨密度呈正相关（γ＝０．５９０２，Ｐ＜０．００１），与病程及血糖呈负相关（γ＝－０．６７６０，－０．４５ １２，Ｐ＜０．０１～０．００１）。血钙、磷、碱性磷酸酶属正常范围。糖尿病患者骨量减少１４例（３０％），骨质疏松１１例（２４％），而对照组骨量减少４例（９％），未发现骨质疏松者。结论：糖尿病患者骨质疏松发生率较高。骨钙素可以作为检测糖尿病性骨质疏松的敏感指标。更多还原

【Abstract】 Objective: To investigate the mechanism of diabetic osteoporosis and the relationship between osteocalcin (BGP) and bone mineral density (BMD) in diabetes. Methods: Serum BGP was determined with radioimmunoassay and BMD was measured with single photon absorphometry in 46 diabetic patients and 46 matched normal subjects respectively, BGP and BMD, serum Ca, P, AKP were compared between the two groups. Results: Both serum BGP and BMD decreased significantly in diabetic patients compared with the control group (P<0.001) .Serum BGP correlated positively with BMD (γ=0.5902, P<0.001) but negatively related to the course of disease and blood glucose (γ=-0.6760, -0.4512, respectively, P<0.01-0.001). Serum Ca, P, AKP were normal. 14 cases in diabetic group (30%) and 4 control subjects (9%) had osteopenia. Osteoporosis was found in 11 cases of diabetes (24%), but in none of the control group. Conclusion: The prevalence of osteoporosis is higher in diabetes than in normal subjects. Measurement of serum BGP can be used as a sensitive index for the diagnosis of diabetic osteoporosis.更多还原