【摘要】 目的　探讨黄体酮对肾缺血 -再灌注损伤的影响。方法　采用小鼠肾缺血—再灌注损伤模型 ,观察肾组织含水量、血清肌酐尿素氮、再灌注 2 4h的生存率及组织病理学变化。结果　与生理盐水组相比 ,黄体酮组在缺血 -再灌注后肾含水量和血清尿素氮水平无明显差异 (P >0 .0 5 ) ,而血清肌酐水平显著升高 (P <0 .0 5 )、2 4h生存率显著降低 (P <0 .0 1)。结论　黄体酮可能加剧肾缺血 -再灌注损伤。更多还原

【Abstract】 Objective To investigate the effects of pregesterone(PROG) on renal damage of ischemia-reperfusion in mice. Method By the model of renal ischemia-reperfusion in mice, the renal contents of water and the levels of serum creatinine(Cr) and blood urea nitrogen (BUN) were detected , and the 24 hour survival rate and the pathological changes of kidney were observed. Result The renal contents of water and the levels of BUN was no difference in PROG group and control group, but Cr was significantly elevated (P<0.05)and the 24h survival rate after reperfusion was reduced significantly(P<0.01). Conclusion PROG may exacerbate the renal injury of ischemia-reperfusion.更多还原