【摘要】 目的 探讨原发性高血压时胰岛素抵抗(IR)与血压昼夜模式改变的关系.方法 对41例原发性高血压(EH组)、42例原发性高血压伴IR(EH+IR组)和30例健康志愿者(对照组)分别检测空腹血糖和胰岛素水平,计算胰岛素敏感指数(ISI),并行24小时动态血压监测,计算夜间血压下降率.结果 与EH组比较,EH+IR组血糖、胰岛素明显升高,ISI降低,收缩压及舒张压夜间下降率减少(P均<0.01).ISI与收缩压及舒张压夜间下降率呈负相关(r=0.645和-0.712,P<0.01).结论 IR与血压昼夜模式改变有关.更多还原

【Abstract】 Objective To study the relationship between insulin resistance (IR) and circadian rhythm alteration of blood pressure pattern in patients with essential hypertension. Methods Fasting plasma glucose and insulin were determined, insulin sensitive index (ISI) were calculated and ambulatory blood pressure in 24 hours were monitored, and reduction percentage of blood pressure in night were calculated in 41 essential hypertensions (EH group),42 essential hypertensions associated with IR (EH + IR group),and 30 healthy control subjects respectively. Results: Fasting plasma glucose and insulin were much higher,as well as ISI was lower and percentage of systolic pressure and diastolic pressure in night were decreased in group EH than those in group EH + IR (P<0. 01 all). ISI were negatively associated with reduced percentage of systolic pressure and diastolic pressure in night (r= - 0. 645 and -0. 712,P<0. 01). Conclusion:IR was associated with circadian rhythm alteration.更多还原