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紫杉醇加顺铂治疗非小细胞肺癌的临床研究

Clinical Trial on the Treatment of Non-Small Cell Lung Cancer with Taxol Plus DDP

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【作者】 张力周中梅马国胜

【Author】 WT5,5”BZ]ZHANG Li,ZHOU Zhong mei,MA Guo sheng (Sun Yat Sen University of Medical Science,Tumor Hospital,Guangzhou 510060,China)

【机构】 中山医科大学肿瘤医院!广东广州510060

【摘要】 :〔目的〕观察紫醇加顺铂方案治疗非小细胞肺癌的疗效及毒副作用。〔方法〕采用顺铂加紫杉醇方案治疗34例初治的非小细胞肺癌病人,所有病人均接受2个疗程化疗。〔结果〕PR15例,无CR病人,有效率为4412%。稳定13例,病情发展6例。病人的主要毒副反应为骨髓抑制、恶心和呕吐、肌痛和关节痛、脱发等。没有观察到威胁生命的严重反应和药物过敏反应,病人耐受良好。〔结论〕顺铂加紫杉醇方案治疗非小细胞肺癌疗效较好,病人耐受性良好,值得在临床上推广使用。

【Abstract】 urpose〕To observe the efficacy and the toxicity of non small cell lung cancer patients treated with taxol plus DDP regimen.〔Methods〕Thirty three initial treated patients with non small cell lung cancer were treated with Taxol plus DDP regimen. All patients received two cycles chemotherapy.〔Results〕The overall response rate was 44.12%,including 15 PR,13 NC,6 PD.The side effects were bone marrow suppression,nausea and vomiting,myalgia and arthritis,alopecia.No life threatening severe side effect and allergic reaction occurred in this clinical trial.〔Conclusion〕Taxol plus DDP is an effective regimen for non small cell lung cancer.It shows this regimen was safe and well tolerated.

【关键词】 非小细胞肺癌化疗紫杉醇顺铂
【Key words】 non small cell lung cancerchemotherapytaxolcisplatin
  • 【文献出处】 浙江肿瘤 ,ZHEJIANG CANCER JOURNAL , 编辑部邮箱 ,2000年01期
  • 【分类号】R734.2
  • 【被引频次】4
  • 【下载频次】36
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