【摘要】 :〔目的〕观察含诺维本的联合化疗方案治疗晚期乳腺癌的疗效和毒副反应。〔方法〕采用NA(E)或NP方案治疗晚期乳腺癌34例。〔结果〕总有效率为588%(20/34),CR147%(5/34),中位生存期14个月。其中初治者有效率为778%(7/9),复治者有效率为520%(13/25)。复治者中14例阿霉素耐药者用NP方案治疗有效率为429%(6/14)。主要毒副作用为骨髓抑制、局部静脉炎、恶心、呕吐。〔结论〕含诺维本联合化疗方案治疗初、复治晚期乳腺癌有效率高,毒副作用可耐受,可作为晚期乳腺癌二线化疗方案。更多还原

【Abstract】 urpose〕To evaluate the efficacy and toxicity of breast cancers.〔Methods〕Thirty four patients with advanced breast cancer were treated with NA(E)or NP regimens.〔Results〕Overall response rate was 58.8%(20/34),included CR 14.7%(5/34). The median survival duration was 14 months.The response rates were 77.8%(7/9) and 52.0%(13/25) for initial treated patients and previous treated patients, respectively. In 25 previous treated cases,response rate was 52.0%(13/25).In 14 adriamycin resistant patients treated with NP regimens, response rate reached 42.9%(6/14). The main toxicities were myelosuppresion,phlebitis and nausea/vomiting.〔Conclusion〕NVB containing regimens are well tolerated with better efficacy in initial treated or previous treated cancer.It may be used as second line regimen for the treatment of advanced breast cancer.更多还原