【摘要】 目的 :探讨重组水蛭素对兔髂总动脉球囊损伤后内膜增殖的影响。方法 :2 4只纯种日本大耳白兔随机分成肝素对照组 (n=12 )和重组水蛭素组 (n=12 ) ,采用兔髂总动脉球囊扩张损伤后内膜增殖动物模型 ,术后 2周和 4周复查血管造影 ,术后 4周处死动物取髂总动脉标本。结果 :用药组术后 2周和 4周平均髂总动脉直径均较对照组明显增加 (P<0 .0 1) ,4周后新生内膜面积显著减少 (P<0 .0 1) ,管腔面积明显扩大 (P<0 .0 1)。结论 :重组水蛭素可显著减轻兔髂总动脉球囊扩张损伤后新生内膜增殖和管腔的狭窄更多还原

【Abstract】 AIM:To evaluate the effect of recombinant hirudin (r hirudin) in reducing neointimal proliferation after balloon angioplasty in rabbits. METHODS:Twenty four rabbits were randomized into r hirudin group ( n =12) and heparin control group ( n =12),Baloon angioplasty were performed on rabbits normal illiac arterial model. Angiograms were performed at 2 weeks and 4 weeks after procedure. Rabbits were killed 4 weeks after angioplasty. RESULTS:The mean common iliac arterial luminal diameter of r hirudin group was significant increased to compare with heparin control group at 2 weeks ( P <0.01) and 4 weeks ( P <0.01) after balloon angioplasty. At 4 weeks after angioplasty,there were the greater luminal areas ( P <0.01) and the less neointimal areas in r hirudin group ( P <0.01) than in heparin control group. CONCLUSION:r hirudin could significantly lessen neointimal proliferation and luminal stenosis of iliac arteries after balloon angioplasty in rabbits.更多还原