【摘要】 目的 :研究二氢可待因控释片对晚期癌痛病人的镇痛作用。方法 :4 7例经病理学确诊的中晚期癌症病人 ,采用随机临床试验 ,口服二氢可待因控释片 ,每次 60～ 1 2 0mg ,每 1 2h一次 ,日剂量 <2 4 0mg ,连用 7d。资料采用t检验或卡方检验作统计处理。结果 :二氢可待因控释片每 1 2h口服一次 ,可以有效地控制晚期癌症慢性中度以上疼痛 ,临床镇痛总有效率为 1 0 0 %。主要不良反应有头晕 ,恶心 ,呕吐 ,胃部不适 ,便秘。结论 :二氢可待因控释片对晚期癌痛有明显的镇痛作用 ,药效持续时间长 ,不良反应小 ,使用方便更多还原

【Abstract】 OBJECTIVE:To study the analgesic effect of dihydrocodeine tartrate controlled release tablets(CDHC) in treatment of pain for cancer patients.METHODS:In a randomized clinical trial,47 diagnosed cancer patients were treated with CDHC(dose 60～120mg,q 12h,7d,total dose<240mg/d).RESULTS:CDHC was effective in the control of moderate to severe cancer related pain while administered every 12 hours and the total effective rate was 100%.The main adverse reactions are drowsiness,dizziness,nausea,vomiting,discomfort in stomach and itching.CONCLUSION:CDHC is effective for pain relieving.Its period of action was long and adverse reactions were slight.更多还原