【摘要】 目的 :合成吉非罗齐 ,并进行工艺改进。方法 :以 2 ,5 二甲基苯酚为起始原料 ,与 1 氯 3 溴丙烷反应 ,得 3 ( 2 ,5 二甲基苯氧基 ) 1 氯丙烷 ,再与异丁酸钠锂作用 ,制得吉非罗齐。结果 :通过两步反应制得产物 ,总收率4 3.8%。醚化反应经优化后收率较文献提高 30 %以上。合成产物经红外光谱、核磁共振谱及质谱确证。结论 :缩短了反应步骤 ,提高了反应收率。更多还原

【Abstract】 OBJECTIVE:To synthesize gemfibrozil and optimize the process.METHOD:Gemfibrozil was synthesized from 3 (2,5 xylyloxyl) propyl chloride which was reacted with sodium isobutyrate first and then react with n butyllithium.3 (2,5 xylyloxyl) propyl chloride was prepared from 2,5 dimethylphenol reacting with 1 bromo 3 chloropropane.RESULTS:Gemfibrozil was synthesized in two steps with the overall yield of 43.8%.The yield of etherification increased by 30% or more as compared with that in literature.The chemical structure of synthetic product were confirmed by IR, 1HNMR,MS.CONCLUSION:The synthetic route was simplized and the overall yield was raised.更多还原