【摘要】 目的：为了探讨Ｕ—７４００６Ｆ对脊髓创伤后线粒体系列酶活性的影响。方法：采用Ａｌｌｅｎ法造成猫脊髓损伤，观察线粒体Ｃａ２＋－Ｍｇ２＋ＡＴＰ酶，Ｎａ＋－Ｋ＋ＡＴＰ酶，超氧化物歧化酶（ＳＯＤ）活性及ＭＤＡ含量的变化。结果：Ｕ－７４００６Ｆ治疗组ＡＴＰ 酶及ＳＯＤ酶活性下降幅度较低，ＭＤＡ含量增加不明显。结论：Ｕ—７４００６Ｆ在脊髓线粒体的病理生理改变中起着重要作用。更多还原

【Abstract】 Objective: To investigate the effect of U - 74006F to series mitochodrial enzyme activaties. Methods: Spinal cord model was performed by Allen method in cats, changes of mitochodrial Na+ - K+ ATPase, Ca2+ - Mg2+ ATPase, Superoxide dismutase(SOD) activaties, contents of malondial dehyde(MDA) were inspected by the different biochemical methods. Results: The activaties of ATP ase and SOD decreased nonsignificantly in U - 74006F group, the content of MDA increased nonsignificantly in U - 74006F group. Conclusion: U- 74006F play importamt roles in mitochodrial pathophysiological alteration after spinal cord injuries.更多还原