【摘要】 目的：研究乙型肝炎病毒基因重组（ＣＨＯ）疫茵对ＨＢｓＡｇ和ＨＢｅＡｇ双阳性母亲所生婴儿的阻断效果。方法：选７０例生于母亲为ＨＢｓＡｇ和ＨＢｓＡｇ双阳性的婴儿，随机分为Ａ组（３１例）和Ｂ组（３９例）。Ａ组为单纯疫苗组，注射３次疫苗（０．ｌ、６月， １０μｇ／次）；Ｂ组为疫苗加乙肝免疫球蛋自（ＨＢＩＧ）组，注射３次疫苗（同Ａ组），并于出生时注射半支（５０ＩＵ）ＨＢＩＧ。全程２～６个月采血，用固相放射免疫（ＲＩＡ）法检测抗－ＨＢｓ、ＨＢｓＡｇ和抗－ＨＢｃ。结果：抗抗－ＨＢｓ阳转率为 ８３．８７％，阻断率为８３．８７％，疫苗加半量乙肝免疫球蛋白（５０ ＩＵ）组分别为９３．１０％和９３．５９％。 结论：乙肝基因重组（ＣＨＯ）疫苗有良好的阻断乙肝母婴传播的效果，如果出生时加注半支ＨＢＩＧ效果更好。更多还原

【Abstract】 Objective To investigate the pretevtive efficacy of recombinant HBsAg vaccine(CHO cell) in prevention of mother - infant transmission of hepatitis Bvirus. Methods Seventy newborn infants born to HBsAg/HbeAg carrier mothers were randomly assigned into two groups. Group A(31 infants) received full - dose HB vaccine at birth, 1 month, and 6 months. 10μg/time, and group B(39 infants) same group A in received vaccine, and injected 50 iu hepatitis B immune globulin(HBIG) at birth. 2 - 6months after full - dose injection infants were taken blood and detected anti - HBs, HBsAg and anti - HBc by RIA method. Results The positive rate of antiHBs were 83. 87% and 93. 10% for group A and group B, respetively. The protective rate were 83. 87% and 93. 59% for grup A and B, respectively. Conclusions The recombinant HBsAg vaccine showed good protective efficacy for in- fants born to HBV carier mothers, if add HBIG at birth the efficacy was better.更多还原