【摘要】 目的：研究络沙坦（Ｌｏｓａｒｔａｎ）对糖尿病肾病内皮素（ＥＴ）、一氧化氮（ＮＯ）及肾功能的影响，探讨络沙坦对糖尿病肾病的防治机制及对肾脏的保护作用。方法：６１例糖尿病肾病患者，随机分为三组：对照组，单用降糖药；依那普利组（降糖药＋Ｅｎａｌａｐｒｉｌ １０ ｍｇ ｑｄ ｐｏ）；络沙坦组（降糖药＋络沙坦５０ ｍｇ ｑｄ ｐｏ）。用药时间８周。结果：络沙坦组与对照组相比， ＥＴ、ＮＯ、ＵＡＥ、ａ１－ＭＧ及Ｓｃｒ（肾功能不全期）治疗后８周均下降，有显著差异（Ｐ＜０．０５）；络沙坦组与Ｅｎａｌａｐｒｉｌ组相比无显著性差异（Ｐ＞０．０５）。结论：络沙坦与血管紧张素转换酶抑制剂（ＡＣＥＩ）同样具有保肾作用，由于ＡＣＥＩ的临床副反应较多，因此络沙坦在临床的应用前景优于ＡＣＥＩ。更多还原

【Abstract】 Objective To investigate the mechanism of Losartan in protecting the renal function of dia- betic nephroparhy. Methods Patients of NIDDM were randomly divided into three groups: the control group(given hypoglycenmic agent); enalapril group(hypoglycemic agent and enalapril 10 mg qd po); losartan group (hypoglycemic agent and losartan 50 mg qd po), Plasma endothelin (ET)level, serum nitric oxide (NO) level, 24 h urinary albumin excretion rate (UAE), 24h urinary, al - MG excretion rate and serum cretinine (Scr) were measured before treatment and at the sib week after treatment separately. Results The level of ET, NO, UAE, a1 - MG and Scr in losartan group were lower than that of control group in the sib week(P<0. 05). There was no difference between Losartan group and Enalapril group (P>0.05). Conclusions Losartan could improve the renal function and decrease the renal tubular injury and protect the kidney from injury as ACEI, because the side effects of ACEI are more, the effects of losartan are more excellent than that of ACEI.更多还原