【摘要】 为探讨低浓度苯及其同系物 (甲苯、二甲苯 )接触对作业女工黄体功能的影响 ,选择某大型石化企业中有苯及其同系物接触的作业女工作为暴露组 ,并以该大型石化企业和某大型化纤企业中无苯及其同系物接触的作业女工为对照组。采用气相色谱法测定作业女工呼吸带空气中的苯、甲苯和二甲苯的浓度 ;对作业女工的月经功能进行前瞻性调查 ;酶免疫分析法测定尿样中的孕二醇 - 3-葡萄糖苷酸 (Pd G)和卵泡刺激素(FSH)。结果显示 ,石化企业苯及其同系物暴露以低浓度苯暴露为主 ;接触低浓度苯及其同系物组女工与对照组相比 ,黄体期长度缩短 (P<0 .0 5或 P<0 .0 1) ,黄体分泌孕酮的能力下降 (P<0 .0 5 )。提示低浓度苯及其同系物暴露可以影响作业女工的黄体功能。尿液激素水平可以作为生殖毒性效应性生物标记物更多还原

【Abstract】 The effect of benzene and its analogues(BIA)on the luteal function of female workers was studied in a petrochemical corporation. The female workers from a chemical fiber corporation without benzene exposure were selected as controls. The levels of BIA(toluene and xylene) in the air at breathing zone were sampled and determined with gas chromatography(GC). The menstrual function was followed up. Urine pregnanediol 3 glucuronide (PdG) and follicular stimulating hormone(FSH) were measured by enzyme immunoassay(EIA). The results showed that BIA existed in low concentration in air. The exposure could lead to a shorter length of time of luteal phase( P <0 05 or P <0 01) and decrease luteal progesterone level ( P <0 05). It was suggested that the low concentration of BIA exposure could have effect on the luteal function in exposed female workers, and urinary hormones could be used as biomarker for the influences of benzene and BIA on reproduction.更多还原